Quick Checklist
- Analgesia & Sedation
- Secure the tube well (use a commercial device)
- Raise head of bed to 30-45°
- Confirm Lung Protective Vent Settings
- Humidify the air (Heat Moisture Exchanger)
- Place Inline Suction (q1h or more)
- End Tidal CO2 Monitor (Pt -> suction -> humidifer -> ETCO2 -> vent)
- Check cuff pressure (20-30 mmH20, use a cuffalator, ask resp Tx)
- Gastric Tube (NG/OG)
- Nebulizers (if any h/o asthma)
- Get an ABG (VBG? only if sat = 90-95% or FiO2 = 30%)
- Check tube depth (CXR)
- Put a BVM at the Bedside ± PEEP Valve
- Run to bed if Vent Alarms
Optional
- Stress Ulcer and DVT Prophylaxis
- Oral Decontamination
Confirm Lung Protective Vent Settings
I: VENTILATOR SETUP AND ADJUSTMENT
- Calculate predicted body weight (PBW)
- Males = 50 + 2.3 [height (inches) – 60]
- Females = 45.5 + 2.3 [height (inches) -60]
- Set ventilator mode: Assist-Control
- Set tidal volume: 6-8 ml/kg PBW (start at 8, titrate down to 6 q2h)
- Set rate: 18 bpm (titrate to pH)
- Adjust VT and RR to achieve pH and plateau pressure goals below.
II: FiO2/PEEP
- Start at 100% and PEEP of 0 or 5.
- Wait 5 minutes and then draw an ABG.
- Then set the FiO2 to 30% and start titrating based on the chart. Go up every 5-10 minutes; quicker if low sats. Use a minimum PEEP of 5 cm H2O. Consider use of incremental FiO2/PEEP combinations such as shown below (not required) to achieve goal.
OXYGENATION GOAL: PaO2 55-80 mmHg or SpO2 90-95%
Lower PEEP/higher FiO2
FiO2 | 0.3 | 0.4 | 0.4 | 0.5 | 0.5 | 0.6 | 0.7 |
---|---|---|---|---|---|---|---|
PEEP | 5 | 5 | 8 | 8 | 10 | 10 | 10 |
FiO2 | 0.7 | 0.7 | 0.8 | 0.9 | 0.9 | 0.9 | 1.0 |
PEEP | 12 | 14 | 14 | 14 | 16 | 18 | 18-24 |
Higher PEEP/lower FiO2
FiO2 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.4 | 0.4 |
---|---|---|---|---|---|---|---|
PEEP | 5 | 8 | 10 | 12 | 14 | 14 | 16 |
FiO2 | 0.5 | 0.5 | 0.5-0.8 | 0.8 | 0.9 | 1.0 | 1.0 |
PEEP | 16 | 18 | 20 | 22 | 22 | 22 | 24 |
III: CHECK PLATEAU PRESSURES (Pplat < 30 cm H2o)
- Plateau pressure must be maintained <30 cm H20.
- Keep lowering the Vt until Plat <30. You may need to go as low as 4 cc/kg
- 0.5 second inspiratory pause
- at least q 4h and after each change in PEEP or VT.
- If Pplat > 30 cm H2O: decrease VT by 1ml/kg steps (minimum = 4 ml/kg).
- If Pplat < 25 cm H2O and VT< 6 ml/kg, increase VT by 1 ml/kg until Pplat>25cmH2OorVT =6ml/kg.
- If Pplat < 30 and breath stacking or dys-synchrony occurs: may increase VT in 1ml/kg increments to 7 or 8 ml/kg if Pplat remains < 30 cm H2O.
IV: ACIDOSIS MANAGEMENT (pH < 7.30)
- If pH 7.15-7.30: Increase RR until pH > 7.30 or PaCO2 < 25 (Maximum set RR = 35).
- If pH < 7.15: Increase RR to 35. If pH remains < 7.15, VT may be increased in 1 ml/kg steps until pH > 7.15 (Pplat target of 30 may be exceeded). May give NaHCO3
- Alkalosis Management: (pH > 7.45) Decrease vent rate if possible.
Achieve Adequate Analgesia and Sedation
Fentanyl Protocol
- Concentration – 1000 mcg in 100 ml D5W or NS (10 mcg/ml)
- Starting Dose – 25 mcg/hr
- Maintenance Dose – 25 to 150 mcg/hr (Max: 150 mcg/hr)
- Titration Dose
- If above pain or below sedation targets, give 25 mcg IV push over 3 to 5 min and increase infusion rate by 25 mcg/hr, q15 min.
- Tapering Dose
- If above sedation and at or below pain targets, decrease infusion rate by 25 mcg/hr, q 1 hr.
- If at sedation and at or below pain targets, decrease infusion by 10 mcg/hr, q1h.
- After interruption, resume at 10 mcg/hr less than previous dose.
Morphine Protocol
- Concentration – 100 mg in 100mL in NS or D5W (1 mg/ml)
- Starting Dose – 0.8 to 10 mg/hr
- Maintenance Dose – 0.8 to 150 mg/hr
- Titration Dose
- When pain score is above target or sedation score is below target, you may push 2 mg of morphine over 4-5 mins & increase rate by 2 mg/hr, q 5 mins.
- Tapering Dose
- When sedation score is above target and if pain score is below target, decrease the infusion rate by 2 mg/hr.
- When sedation score is at target and pain score is below target, decrease the infusion rate by 0.5 mg/hr increments.